Increased duration of OTC painkiller use increases risk of hearing loss

Researchers say their findings suggest that a “significant proportion” of hearing loss is owed to paracetamol or NSAID-related ototoxicity. Previous research has linked use of analgesics to an increased risk of hearing loss, but it is unclear if this is affected by duration of painkiller use. To investigate, researchers from the Brigham and Women’s Hospital … Continue reading Increased duration of OTC painkiller use increases risk of hearing loss

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New oral anticoagulants for stroke prevention in atrial fibrillation

Around 12,500 strokes are caused by atrial fibrillation (AF) in the UK each year, and 7,100 of these are preventable with appropriate anticoagulation. Four new oral anticoagulants (NOACs) are now available in the UK in addition to warfarin.  Timeline of key events Dabigatran and rivaroxaban were approved in the EU in 2011 following publication … Continue reading New oral anticoagulants for stroke prevention in atrial fibrillation

Understanding the chemical basis of drug stability and degradation

The metabolism of drugs occurs through basic chemical reactions as soon as the administered compound comes into contact with enzymes that are capable of altering its chemical structure. Conversely, a drug’s stability after administration is due mainly to its lack of transformation by the body’s enzymes. However, many drugs are susceptible to some form of … Continue reading Understanding the chemical basis of drug stability and degradation